The leopard (multiple lentigines) syndrome: a case report.

Lentigines are small brown macules in the skin characterised histopathologically by an increased number of melanocytes at the dermo-epidermal junction. Profuse lentigines, first described in the literature as 'lentiginosis profusa' was thought to be a dermatologic oddity. Later reports appeared of an association with cardiac abnormalities and sexual infantilism. I Based on further observations, Gorlin and Anderson 2 in 1969 tied together a melange of manifestations that are associated with profuse lentigines and establised the LEOPARD syndrome, named acrostically from the main findings as follows: L lentigines, E e1ectrocardiographic conduction abnormalities (usually bundle branch blocks), 0 ocular hyperte1orism, P pulmonary stenosis (other cardiac abnormalities like aortic stenosis and hypertrophic cardiomyopathy have also been reported, 3.5 A abnormalities of genitalia (usually hypospadias and cryptorchidism), R retardation of growth, D Deafness (sensori-neural).